Project Summary
In project P10, we will investigate how modulating the ER stress regulator ATF6α in liver parenchymal and immune cells may be leveraged for liver cancer therapy. Using mouse models, human patient cohorts, clinical trial datasets, and in vitro systems, we will examine the transcriptional programs controlled by ATF6α and its interactions with oncogenic, tumour suppressor and other ER stress pathways (Aim 1). Furthermore, we will assess how ATF6α activity shapes the tumour immune microenvironment, including its role in hepatocytes and directly in immune cells associated with liver cancer (Aim 2).
