Fetsch V, Schwöbel L, Ozyerli-Goknar E, Stell AV, Punta M, Plenge T, Klaus T, Gupta MK, Andrieux G, Shoumariyeh K, Pfeiffer S, Corrales E, Schlenke L, Baniadam H, Brandl SM, Andreis M, Remen M, Hartmann A, Grueter K, Zwick M, Köhler N, Kuban M, Metzger E, Rummelt C, Duyster J, Boerries M, Hofmann M, Färber J, Braun LM, Zähringer A, Lübbert M, Toffalori C, Vago L, Heidel FH, Minguet S, Apostolova P, Feuchtinger T, Maas-Bauer K, Blaeschke F, Kühn MWM, Timmers HTM, Wertheimer T, Perner F, Zeiser R. Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML. Blood. 2026 Jan 29;147(5):584-601. doi: 10.1182/blood.2025029712.

 

Highlighted by: Chakraverty R. Menin inhibitors: a 2-in-1 defense versus AML immune evasion. Blood (2026) 147 (5): 482–483.

Duque-Afonso J, Rummelt C, Förster K, Zeiser R, Mougiakakos D. BCMA-CD3 T-cell engager as salvage therapy for multirefractory primary immune thrombocytopenia. Lancet. 2026 Jan 23:S0140-6736(25)02515-2. doi: 10.1016/S0140-6736(25)02515-2. Epub ahead of print.

Traichel J, Metzger A, Walz M, Feuerstein R, Wohlfeil N, Metzger P, Marx L, Asdih C, Lindenthal A, Seger A, Schrimpf J, Nardella LL, Kowar S, Frew IJ, Halbach S, Kesselring R, Boerries M, Griffin R, Brummer T. Novel syngeneic cell lines for studying high-risk BRAFV600E-driven colorectal cancer in vivo. Cancer Res Commun. 2026 Jan 22. doi: 10.1158/2767-9764.CRC-25-0599. Epub ahead of print.

Gu J, Li Y, Chen Q, Song Z, Qian Q, Liang Y, Huang T, Qiao L, Li X, Yu M, Liu M, Zhou J, Shao Q, Xu X, Zeiser R, Lu L. Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity. Cell. 2026 Jan 22;189(2):418-434.e24. doi: 10.1016/j.cell.2025.11.034. Epub 2025 Dec 24.

Hafner P, Keller SJ, Chen X, Alrawashdeh A, Jumaa H, Nollmann FI, Besson S, Kemming J, Gorka O, Das T, Appiah B, Lehmann A, Li M, Apostolova P, Bengsch B, Zeiser R, Tholen S, Schilling O, Groß O, Vlachos A, Wittel UA, von Elverfeldt D, Reichardt W, Boerries M, Andrieux G, Heynen GJ, Fichtner-Feigl S, Hannibal L, Ruess DA. Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. Signal Transduct Target Ther. 2026 Jan 16;11(1):33. doi: 10.1038/s41392-025-02563-7.

Zwick M, Zinkel B, Spohr C, Rückert T, Halbach S, Shoumariyeh K, Scheid J, Baur AS, Braun LM, Angel M, Michaeli E, Todkar A, Nelde A, Märklin M, Holzmayer SJ, Dicks S, Boerries M, Duquesne S, Schlaak AE, Otto-Mora P, Bengsch B, Schiff M, Kissel S, Selle M, Follo M, Altmann H, Kunadt D, Illert AL, Walz JS, Walz G, Duyster J, Schetelig J, Brummer T, Zeiser R, Köhler N. FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia. Cancer Res. 2026 Jan 16;86(2):367-386. doi: 10.1158/0008-5472.CAN-25-0349.

Tangermann C, Ghosh A, Ziegler M, Facchinetti F, Stappenbeck J, Carus Sahin YO, Riester M, Viardot LC, Zundel T, Friboulet L, Hollebecque A, Naveja JJ, Wanninger A, Hess ME, Brummer T, Boerries M, Loges S, Loriot Y, Illert AL, Diederichs S. Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations. Nat Genet. 2026 Jan;58(1):157-168. doi: 10.1038/s41588-025-02431-8. Epub 2025 Dec 8.

Braun LM, Zeiser R. Cutting without cleaving: How caspase-1 shapes leukemia beyond enzymatic activity. Cell Chem Biol. 2026 Jan 15;33(1):1-3. doi: 10.1016/j.chembiol.2025.12.011.

Watter M, Giuliani C, Benadi G, Engel F, Binder H, Kaier K. Automated identification of contextually relevant biomedical entities with grounded LLMs. Sci Rep. 2026 Jan 13;16(1):1952. doi: 10.1038/s41598-026-35492-8.

Kaier K, Engel F, Benadi G, Giuliani C, Watter M, Kalantari A, Schuller K, Franzke CW, Sperandio M, Binder H. Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. BMC Res Notes. 2026 Jan 12;19(1):43. doi: 10.1186/s13104-026-07632-w.PMC12837611.

Gawron J, Czech M, Rückert T, Holzmüller V, Andreev G, Burk AC, Hartmann A, Chatterjee S, Andrieux G, Marquard FE, Baur AS, Stell AV, Krausz M, Braun LM, Osswald N, Melchinger W, Wertheimer T, Proano-Vasco AI, Maas-Bauer K, Schmitt-Graeff A, Boerries M, Köhler N, Ayuk FA, Schell C, Quante M, Zeiser R. Gastrin for the treatment of acute graft-versus-host disease of the stomach. Blood. 2026 Jan 9:blood.2025031080. doi: 10.1182/blood.2025031080. Epub ahead of print.

Bakırdöğen D, Görgülü K, Xin J, Richter L, Alcalá S, Ruiz-Cañas L, Dai C, Frank KJ, Wu N, Diakopoulos KN, Ozturk H, Demircioğlu D, Peschke K, Ranjan R, Fusco F, Martinez-Useros J, Fernandez-Aceñero MJ, Chhabra NF, López-Gil JC, Ai J, Ruess DA, Kaya-Aksoy E, Schmidt F, Kohlmann L, Berninger A, Yangin H, Schicktanz F, Steiger K, Demir IE, Schmid RM, Reichert M, Adli M, Lesina M, Sainz B Jr, Algül H. c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT. Mol Cancer. 2025 Dec 15. doi: 10.1186/s12943-025-02486-5. Epub ahead of print.

Giuliani C, Benadi G, Engel F, Werner J, Watter M, Schwarzer G, Groß O, Zeiser R, Binder H, Kaier K. Identifying Biomedical Entities for Datasets in Scientific Articles: 4-Step Cache-Augmented Generation Approach Using GPT-4o and PubTator 3.0. JMIR Form Res. 2025 Nov 20;9:e73822. doi: 10.2196/73822.

Lalioti ME, Romero-Mulero MC, Karabacz N, Mess J, Demollin H, Rettkowski J, Schuldes K, Mitterer M, Wadle C, Shoumariyeh K, Egg M, Alfonso-Gonzalez C, Jäcklein K, Schönberger K, Karantzelis N, Reisig G, Aktories P, Mayer IM, Tsoukala I, Schäffer A, Tirado-Gonzalez I, Dugourd A, Braun LM, Silva-Rego B, Jones MJ, Kierdorf K, Saez-Rodriguez J, Reising K, Walter SG, Medyouf H, Hilgers V, Ghiaur G, Zeiser R, Karpova D, Renders S, Gravius S, Buescher J, Cabezas-Wallscheid N. Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells. Nat Cell Biol. 2025 Jul 15. doi: 10.1038/s41556-025-01709-7. Epub ahead of print.

Ardura-Fabregat A, Bosch LFP, Wogram E, Mossad O, Sankowski R, Aktories P, Kieger L, Cook J, Hasavci D, Ulupinar H, Brock D, Wang F, Iovino N, Wald S, Preissl S, Yilmaz B, Schnepf D, Macpherson AJ, Blank T, Kierdorf K, Prinz M. Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease. Nat Neurosci. 2025 Jul 14. doi: 10.1038/s41593-025-02006-0. Epub ahead of print.

Chatterjee S, Rückert T, Martin I, Michaeli E, Buescher J, Apostolova P, Erny D, Lalioti ME, Biavasco F, Hartmann A, Runge S, Braun LM, Talvard-Balland N, Adams RC, Schmitt-Graeff A, Cook J, Wenger V, Athanassopoulos D, Hasavci D, Vallejo-Janeta AP, Blank T, Schaible P, Vinnakota JM, Zähringer A, Ganal-Vonarburg SC, Melchinger W, Pfeifer D, Köhler N, Rosshart SP, Michonneau D, Socié G, Andrieux G, Cabezas-Wallscheid N, Boerries M, Prinz M, Zeiser R. Gut microbiota-derived TMAVA is a modulator of acute CNS-GVHD. J Exp Med. 2025 Sep 1;222(9):e20242180. doi: 10.1084/jem.20242180. Epub 2025 Jul 8.

Peighambari A, Huang H, Metzger P, Adlesic M, Zodel K, Schäfer S, Seidel P, Braun LM, Hülsdünker J, Melchinger W, Follo M, Ku M, Haug S, Li Y, Köttgen A, Schell C, von Elverfeldt D, Reichardt W, Zeiser R, Heikenwalder M, Höfflin R, Börries M, Frew IJ. Characterisation of an autochthonous mouse ccRCC model of immune checkpoint inhibitor therapy resistance. Sci Rep. 2025 Jun 5;15(1):19818. doi: 10.1038/s41598-025-04917-1.

Gorantla SP, Rassner M, Crossley KA, Müller TA, Poggio T, Khaja Saleem S, Kleinfelder H, Gambheer SMM, Endres C, Schaberg S, Schmidt D, Prince G, Gonzalez-Menendez I, Bentrop D, Trittler R, Rylova S, Pfeifer D, Andrieux G, Quintanilla-Martinez L, Illert AL, von Bubnoff N, Zeiser R, Duyster J. Efficacy of JAK1/2 inhibition in murine myeloproliferative neoplasms is not mediated by targeting oncogenic signaling. Nat Commun. 2025 May 24;16(1):4833. doi: 10.1038/s41467-025-60019-6.

Ho NHJG, Talvard-Balland N, Köhler N, Zeiser R. Immune Escape of Acute Myeloid Leukemia after Transplantation. Blood Cancer Discov. 2025 May 5;6(3):168-181. doi: 10.1158/2643-3230.BCD-24-0063.