The role of oncogene induced Oncostatin M in reprogramming the stem cell niche and promoting immune escape of leukaemia

Project Summary

In this project we will assess how Oncostatin M (OSM) secreted by malignant myeloid cells upon oncogene activation causes metabolic changes and exhaustion in T cells. The functional role of the oncogene/OSM axis will be analysed in genetic leukaemia mouse models that rely on OSM, OSM(R) receptor or cytokine knockout or overexpression. The effect of OSM on T cell metabolism, phenotype and function will be studied in these mouse models and in cell co-culture approaches. OSM expression will be correlated with patient outcome in human myeloid malignancies.