Projects

Franziska Blaeschke
Robert Zeiser

Counteracting NRAS- and c-KIT-driven immune escape in AML by kinase inhibition and T-cell reprogramming

Florian Greten

Targetable modifiers of T cell exclusion in KrasG12D-driven colorectal cancer liver metastases

Natalie Köhler
Priscilla Briquez

Effects of cKit-D816V and FLT3-ITD on tissue factor-mediated immune escape in acute myeloid leukaemia

Petya Apostolova
Katrin Kierdorf

Flt3-ITD-induced remodelling of non-leukaemic myeloid cells and its role in leukaemic immune escape

Marco Prinz

Dissecting myeloid subset-specific effects of the IDH1 mutation in high-grade glioma

Ian Frew

Therapeutic exploitation of immunosuppressive aberrant tubular repair in VHL mutant clear cell renal cell carcinoma

Mathias Heikenwälder
Maike Hofmann

Targeting the parenchymal and immune proto-oncogenic ER-stress/ ATF6 - axis in liver cancer

Justus Duyster
Julia Kolter

Oncogenic BRAF-V600E drives immune escape via prostaglandin E2/oncostatin M production in melanoma

Tilman Brummer

Overcoming immune evasion of BRAF mutant colorectal cancer

Susana Minguet

Engineering γδT cells to target oncogenic hubs

Dietrich Ruess
Bertram Bengsch

Dual RAS/SHP2 inhibition for sensitization of pancreatic cancer to immunotherapy

Rouven Hoefflin
Lisa Sevenich

Impact of oncogenic IDH mutation on the extracellular matrix to mediate immune evasion in glioma

Maike Hofmann
Natascha Röhlen

Focal adhesion kinase (FAK) dependent immune escape in hepatocellular carcinoma

Eric Metzger

Targeting KMT9 to reprogramme immune cells in the tumour immune microenvironment in prostate cancer

Jan Philipp Böttcher

Targeting the COX-PGE2-EP2/EP4 axis to overcome immune escape in KRAS-G12D-mutant PDAC

Tobias Feuchtinger
Kristina Maas-Bauer

Overcoming immune escape of KMT2A-rearranged acute leukaemia during immune recognition

Florian Ingelfinger
Lisa Sevenich

Spatio-temporal Analysis of Immune Evasion Mechanisms in AKT1-mutant Brain Metastasis

Janaki Manoja Vinnakota
Tobias Wertheimer

Restoring immune surveillance in post-transplant AML by targeting the c-MYC/FLT3-ITD/TAK1 axis

Heike Pahl
Marta Rizzi

Oncogenic NFE2 induces immunosuppressive TGF-β in the bone marrow microenvironment of myeloproliferative diseases

Melanie Börries
Anna Köttgen
Christoph Schell

Data analysis, integration, and modelling

Wilfried Reichardt
Nana Talvard-Balland

Preclinical Imaging and NMR Spectroscopy

Harald Binder

Information Infrastructure for Research Data Management

Robert Zeiser

Central tasks of the Collaborative Research Centre

Melanie Börries

Integrated Research Training Group (IRTG) for Oncogene-driven immune escape

Miriam Erlacher

Understanding the crosstalk between juvenile myelomonocytic leukaemia (JMML) and immune cells

Olaf Groß

Oncogene-driven inflammasome activity in myeloid neoplasms and its impact on leukaemia development and anti-cancer immunity

Lena Illert

The role of the NPM-ALK / PD-1 axis for immune response to T cell lymphoma

Alexander Nyström
Dimitra Kiritsi

The role of HRAS downstream signalling for the production of immunosuppressive metabolites in the microenvironment of HRAS-driven SCC

Nina Cabezas-Wallscheid

Oncogene-driven adenosine production by leukaemic stem cells promotes their immune escape

Oliver Schilling

Data analysis, integration, and modelling