Oncogene-driven immune escape (OncoEscape)
Collaborative Research Centre 1479
The Collaborative Research Center (CRC) 1479 “Oncogene-driven immune escape” is a research consortium of clinical and basic tumor biologists and immunologist. Our CRC builds on the scientific hypothesis that oncogenic signalling and immune escape mechanisms are closely connected. This concept implies that targeting of oncogene-driven immune evasion could take treatment beyond palliative therapy towards cures for different types of cancer.
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Peñarando J, Willmann D, Sum M, Jia Y, Berlin C, Braun LM, Chen Z, Urban S, Jung M, Duteil D, Metzger D, Gratzke C, Zeiser R, Greschik H, Schüle R, Metzger E. KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer. Mol Cancer. 2026 Sep 17;25(1):223. doi: 10.1186/s12943-026-02801-8.
Holzmüller V, Gawron J, Burk AC, Stell AV, Baur AS, Zähringer A, Fetsch V, Mäder A, Hartmann A, Talvard-Balland N, Krishna N, Cunnion K, Thienel U, Martini P, Glenn L, Ferrara JL, Al Malki MM, Choe H, Pérez-Simón JA, Schmitt-Graeff A, Buescher J, Köhler N, Mansoori Moghadam Z, Henneke P, Andrieux G, Boerries M, Zeiser R. Pegtarazimod limits acute graft-versus-host disease mortality and severity in mice and is tolerated in patients. J Clin Invest. 2026 Aug 4:e205864. doi: 10.1172/JCI205864. Epub ahead of print.
Poggio T, Gräßel L, Andrieux G, Gómez Martínez AM, Stock K, Kršić M, Gonzalez Menendez I, Kreutmair S, Orcinha C, Russ M, Yacob S, Miething C, Bonofiglio F, Montes-Mojarro IA, Köhler N, Follo M, Pfeifer D, Fend F, Quintanilla-Martinez L, Chiarle R, Voena C, Jung J, Zeiser R, Turner SD, Boerries M, Duyster J, Illert AL. CD4+ T cells orchestrate the immune response to ALK-positive T-cell lymphoma. Blood. 2026 Jul 28:blood.2026033240. doi: 10.1182/blood.2026033240. Epub ahead of print
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