Oncogene-driven immune escape (OncoEscape)
Collaborative Research Centre 1479

The Collaborative Research Center (CRC) 1479 “Oncogene-driven immune escape” is a research consortium of clinical and basic tumor biologists and immunologist. Our CRC builds on the scientific hypothesis that oncogenic signalling and immune escape mechanisms are closely connected. This concept implies that targeting of oncogene-driven immune evasion could take treatment beyond palliative therapy towards cures for different types of cancer.

Our Research Program

Publications

Bakırdöğen D, Görgülü K, Xin J, Richter L, Alcalá S, Ruiz-Cañas L, Dai C, Frank KJ, Wu N, Diakopoulos KN, Ozturk H, Demircioğlu D, Peschke K, Ranjan R, Fusco F, Martinez-Useros J, Fernandez-Aceñero MJ, Chhabra NF, López-Gil JC, Ai J, Ruess DA, Kaya-Aksoy E, Schmidt F, Kohlmann L, Berninger A, Yangin H, Schicktanz F, Steiger K, Demir IE, Schmid RM, Reichert M, Adli M, Lesina M, Sainz B Jr, Algül H. c-Rel drives pancreatic cancer metastasis through fibronectin-integrin signaling-induced isolation stress resistance and EMT. Mol Cancer. 2025 Dec 15. doi: 10.1186/s12943-025-02486-5. Epub ahead of print.
Lalioti ME, Romero-Mulero MC, Karabacz N, Mess J, Demollin H, Rettkowski J, Schuldes K, Mitterer M, Wadle C, Shoumariyeh K, Egg M, Alfonso-Gonzalez C, Jäcklein K, Schönberger K, Karantzelis N, Reisig G, Aktories P, Mayer IM, Tsoukala I, Schäffer A, Tirado-Gonzalez I, Dugourd A, Braun LM, Silva-Rego B, Jones MJ, Kierdorf K, Saez-Rodriguez J, Reising K, Walter SG, Medyouf H, Hilgers V, Ghiaur G, Zeiser R, Karpova D, Renders S, Gravius S, Buescher J, Cabezas-Wallscheid N. Differentiation, ageing and leukaemia alter the metabolic profile of human bone marrow haematopoietic stem and progenitor cells. Nat Cell Biol. 2025 Jul 15. doi: 10.1038/s41556-025-01709-7. Epub ahead of print.
Ardura-Fabregat A, Bosch LFP, Wogram E, Mossad O, Sankowski R, Aktories P, Kieger L, Cook J, Hasavci D, Ulupinar H, Brock D, Wang F, Iovino N, Wald S, Preissl S, Yilmaz B, Schnepf D, Macpherson AJ, Blank T, Kierdorf K, Prinz M. Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease. Nat Neurosci. 2025 Jul 14. doi: 10.1038/s41593-025-02006-0. Epub ahead of print.
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