Olaf Groß
Principal Investigator
Institute of Neuropathology
Medical Center University of Freiburg
Breisacher Str. 64
79106 Freiburg
- +49 761 270-63079
- olaf.gross@uniklinik-freiburg.de
- Homepage
Current position
Academic training
| 1997 - 2003 | Biology study (Dipl. Biol.), Technical University of Munich, Germany |
Advanced academic qualifications
| 2014 | Habilitation in Molecular Medicine, Technical University of Munich |
| 2008 | Dissertation (Dr. rer. nat.), Technical University of Munich |
Postgraduate positions
| Since 2017 | Full Professor (W3) for Experimental Neuropathology, Head of Metabolism and Inflammation Laboratory, Medical Center University of Freiburg |
| 2012 - 2017 | Independent Research Group Leader, Medical Center Technical University of Munich |
| 2008 - 2012 | Postdoctoral Research Fellow, Department of Biochemistry, University of Lausanne, Switzerland |
| 2003 - 2008 | Dissertation, Technical University of Munich |
Miscellaneous (Honors, Awards)
| 2021 | ERC Proof-of-Concept Grant (EU) |
| 2014 | ERC Starting Grant (EU) |
| 2012 | Independent Junior Research Group funding within the Bavarian Research Network for Molecular Biosystems |
| 2009 | EMBO long-term Fellowship |
| 2009 | Robert-Koch Post-doctoral Award in Immunology |
| 2006 | Young Scientist Award of the German Society for Haematology and Oncology |
Publications listed in PubMed®
Publications (based on CRC1479 funding)
Neuwirt E, Magnani G, Ćiković T, Wöhrle S, Fischer L, Kostina A, Flemming S, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker CN, Boettcher A, Farady CJ, Kesselring R, Berlin C, Backofen R, Rodriguez-Franco M, Kreutz C, Prinz M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. Tyrosine kinase inhibitors can activate the NLRP3 inflammasome in myeloid cells through lysosomal damage and cell lysis. Sci Signal. 2023 Jan 17;16(768):eabh1083. doi: 10.1126/scisignal.abh1083. Epub 2023 Jan 17.
Grüninger PK, Uhl F, Herzog H, Gentile G, Andrade-Martinez M, Schmidt T, Han K, Morgens DW, Bassik MC, Cleary ML, Gorka O, Zeiser R, Groß O, Duque-Afonso J. Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia. Cancer Gene Ther. 2022 Nov;29(11):1751-1760. doi: 10.1038/s41417-022-00491-0.
Aktories P, Petry P, Glatz P, Andrieux G, Oschwald A, Botterer H, Gorka O, Erny D, Boerries M, Henneke P, Groß O, Prinz M, Kierdorf K. An improved organotypic cell culture system to study tissue-resident macrophages ex vivo. Cell Rep Methods. 2022 Jul 26;2(8):100260. doi: 10.1016/j.crmeth.2022.100260.
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