Publications based on CRC1479 funding
Matsuki E, Miyata M, Sato R, Gawron J, Suto M, Tamaki H, Fujiwara H, Ito A, Hishima T, Ishizawa Y, Sekiguchi E, Tobai T, Ushio S, Oravecz-Wilson K, Chen G, Tawara I, Ichikawa K, Watanabe M, Ishizawa K, Yokoyama H, Peltier D, Blazar B, Zeiser R, Reddy P, Toubai T. NLRP6 regulates donor T cell activation and acute graft-versus-host disease via ZAP-70-Erk pathway. Haematologica. 2026 Jul 2. doi: 10.3324/haematol.2025.289144. Epub ahead of print.
Ozyerli-Goknar E PhD, Nizamuddin S, Fetsch V, Biniossek ML, Hartmann A, Perner F, McGeehan GM, Armstrong SA, Zeiser R, Timmers HTM. Menin-MLL inhibitors enhance JUND activity in MLLr leukemic cells contributing to tumorigenesis and therapy resistance. Blood. 2026 Jun 29:blood.2025032363. doi: 10.1182/blood.2025032363. Epub ahead of print.
Fleischhauer K, Toffalori C, Cugnata F, Hofmann JA, Orofino G, Lorentino F, Ahci-Hanci M, Lange V, Müller CR, Kunadt D, Bornhäuser M, Sanz G, Soiffer R, Waterhouse M, Giaccone L, Ali H, Nachtkamp K, Bacigalupo A, Bonifazi F, Luznik L, Facchini L, Bramanti S, Nagler A, Saccardi R, Milano F, Zallio F, Pierini A, Mohty M, Flomenberg N, Takaori-Kondo A, Vey N, Teshima T, Kröger N, Laperche CM, Andreani M, Lupo Stanghellini MT, Peccatori J, Di Serio C, Kobbe G, Al Malki MM, Bruno B, Zeiser R, Lindsley RC, Sanz J, Beelen D, Stölzel F, Sauter J, Schmidt AH, Ciceri F, Vago L; HLALOSS Consortium. Donor Selection and Human Leukocyte Antigen Loss Leukemia Relapse After Hematopoietic Cell Transplantation. J Clin Oncol. 2026 Jun 25:JCO2600113. doi: 10.1200/JCO-26-00113. Epub ahead of print.
Rahbari M, Gris-Oliver A, Ramadori P, Aicher D, Sia D, Malek NP, Loomba R, Bataller R, Llovet JM, Heikenwälder M. The versatile interplay between steatotic liver disease and liver cancer. Nat Rev Cancer. 2026 Apr 14. doi: 10.1038/s41568-026-00918-y. Epub ahead of print.
Gawron J, Czech M, Rückert T, Holzmüller V, Andreev G, Burk AC, Hartmann A, Chatterjee S, Andrieux G, Marquard FE, Baur AS, Stell AV, Krausz M, Braun LM, Osswald N, Melchinger W, Wertheimer T, Proano-Vasco AI, Maas-Bauer K, Schmitt-Graeff A, Boerries M, Köhler N, Ayuk FA, Schell C, Quante M, Zeiser R. Gastrin for the treatment of acute graft-versus-host disease of the stomach. Blood. 2026 Apr 9;147(15):1763-1778. doi: 10.1182/blood.2025031080.
Highlighted by: Chakraverty R. GVHD fails the acid test. Blood. 2026 Apr 9;147(15):1660-1662.
Maas-Bauer K, Meyer T, Yücel M, Garofalaki M, Koßmann S, Biavasco F, Lysandrou M, Waterhouse M, Feuchtinger T, Pfeifer D, Ingelfinger F, Wertheimer T, Duyster J, Ahn JS, Soiffer RJ, Finke J, Wäsch R, Spyridonidis A, Kim DDH, Wehr C, Zeiser R. Mutational landscape changes of AML in patients relapsing after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2026 Apr 3. doi: . Epub ahead of print.
Braun LM, Naidoo J, Zeiser R. Immune-mediated side effects of cancer immunotherapies. Blood. 2026 Mar 9:blood.2025030059. doi: 10.1182/blood.2025030059. Epub ahead of print.
Chhatbar C, Sankowski R, Schulz M, Shimizu T, Schwabenland M, Staszewski O, Scheiwe C, Nessler S, Borst K, Dumas AA, Trost E, Berchtold D, Brandão W, Mossad O, Dalmau Gasull A, Frosch M, Erny D, Diebold M, Guffart E, Ternka K, Guranda M, Vinnakota JM, Friesen M, Ouk K, Waltl I, LaMorte M, Hammond TR, Di Liberto G, Vincenti I, Kreutzfeldt M, Mughrabi IT, Al-Abed Y, Blank T, Meyer-Luehmann M, Crow YJ, Hagen N, Ofengeim D, Zeiser R, Kettwig M, Gärtner J, Meisel A, Schwemmle M, Kalinke U, Beck J, Bengsch B, Thimme R, Butovsky O, Seredenina T, Ransohoff RM, Quintana FJ, Kierdorf K, Merkler D, Stadelmann C, Priller J, Prinz M. A transcriptomic microglia taxonomy across mouse and human pathologies. Nat Immunol. 2026 Mar 25:10.1038/s41590-026-02472-z. doi: 10.1038/s41590-026-02472-z. Epub ahead of print.
Heitmann JS, Maringer Y, Jung S, Wacker M, Hackenbruch C, Polster M, Marconato M, Nelde A, Bauer J, Zwick M, Baur AS, Metzger A, Krolla C, Andrieux G, Köhler N, Boerries M, Denk M, Zieschang L, Kammer C, Hoenisch-Gravel N, Richter M, Oezbek MT, Wirths S, Dengler A, Dubbelaar ML, Pumptow M, Martus P, Brüggemann M, Rammensee HG, Salih HR, Walz JS. Personalised multipeptide-based T-cell activator for chronic lymphocytic leukaemia: an open-label, single-centre, phase 1 study. Lancet Haematol. 2026 Feb;13(2):e74-e85. doi: 10.1016/S2352-3026(25)00323-0. Epub 2026 Jan 14. Erratum in: Lancet Haematol. 2026 Feb;13(2):e58. doi: 10.1016/S2352-3026(26)00012-8.
Li X, Lebeaupin C, Kadianaki A, Druelle-Cedano C, Vesper N, Rennert C, Huguet-Pradell J, Gomez Ramos B, Fan C, Piecyk RS, Zizmare L, Ramadori P, Li L, Frick L, Qiu M, Zhang C, Martins Nascentes Melo L, Ranvir VP, Shen P, Hanselmann J, Kosla J, Fernández-Vaquero M, Vucur M, Baskaran P, Bao X, Coleman OI, Tang Y, Cetin M, Chen Z, Jang I, Del Prete S, Rahbari M, Zhang P, Pham TV, Hou Y, Sun A, Gu L, Kim LC, Rothermel U, Heide D, Ali A, Gallage S, Talvard-Balland N, Piqué-Gili M, Gris-Oliver A, Bevilacqua A, Schlicker L, Duffey A, Unger K, Szydlowska M, Hetzer J, Odom DT, Machauer T, Bucci D, Sant P, Lee JH, Rösler J, Meckelmann SW, Schreck J, Murray S, Simon MC, Nahnsen S, Schulze A, Ho PC, Jugold M, Breuhahn K, Mallm JP, Schirmacher P, Roth S, Rahbari N, Tschaharganeh DF, Roessler S, Goeppert B, Bengsch B, Andrieux G, Boerries M, Malek NP, Prinz M, Weber A, Zeiser R, Tamayo P, Bronsert P, Kurowski K, Thimme R, Yuan D, Carretero R, Luedde T, Pinyol R, Hartmann FJ, Karin M, Tasdogan A, Trautwein C, Mall M, Hofmann M, Llovet JM, Haller D, Kaufman RJ, Heikenwälder M. Activated ATF6α is a hepatic tumour driver restricting immunosurveillance. Nature. 2026 Mar;651(8106):796-807. doi: 10.1038/s41586-025-10036-8. Epub 2026 Feb 4.
Fetsch V, Schwöbel L, Ozyerli-Goknar E, Stell AV, Punta M, Plenge T, Klaus T, Gupta MK, Andrieux G, Shoumariyeh K, Pfeiffer S, Corrales E, Schlenke L, Baniadam H, Brandl SM, Andreis M, Remen M, Hartmann A, Grueter K, Zwick M, Köhler N, Kuban M, Metzger E, Rummelt C, Duyster J, Boerries M, Hofmann M, Färber J, Braun LM, Zähringer A, Lübbert M, Toffalori C, Vago L, Heidel FH, Minguet S, Apostolova P, Feuchtinger T, Maas-Bauer K, Blaeschke F, Kühn MWM, Timmers HTM, Wertheimer T, Perner F, Zeiser R. Menin inhibition enhances graft-versus-leukemia effects by T-cell activation and endogenous retrovirus induction in AML. Blood. 2026 Jan 29;147(5):584-601. doi: 10.1182/blood.2025029712.
Highlighted by: Chakraverty R. Menin inhibitors: a 2-in-1 defense versus AML immune evasion. Blood (2026) 147 (5): 482–483.
Duque-Afonso J, Rummelt C, Förster K, Zeiser R, Mougiakakos D. BCMA-CD3 T-cell engager as salvage therapy for multirefractory primary immune thrombocytopenia. Lancet. 2026 Jan 23:S0140-6736(25)02515-2. doi: 10.1016/S0140-6736(25)02515-2. Epub ahead of print.
Traichel J, Metzger A, Walz M, Feuerstein R, Wohlfeil N, Metzger P, Marx L, Asdih C, Lindenthal A, Seger A, Schrimpf J, Nardella LL, Kowar S, Frew IJ, Halbach S, Kesselring R, Boerries M, Griffin R, Brummer T. Novel syngeneic cell lines for studying high-risk BRAFV600E-driven colorectal cancer in vivo. Cancer Res Commun. 2026 Jan 22. doi: 10.1158/2767-9764.CRC-25-0599. Epub ahead of print.
Gu J, Li Y, Chen Q, Song Z, Qian Q, Liang Y, Huang T, Qiao L, Li X, Yu M, Liu M, Zhou J, Shao Q, Xu X, Zeiser R, Lu L. Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity. Cell. 2026 Jan 22;189(2):418-434.e24. doi: 10.1016/j.cell.2025.11.034. Epub 2025 Dec 24.
Hafner P, Keller SJ, Chen X, Alrawashdeh A, Jumaa H, Nollmann FI, Besson S, Kemming J, Gorka O, Das T, Appiah B, Lehmann A, Li M, Apostolova P, Bengsch B, Zeiser R, Tholen S, Schilling O, Groß O, Vlachos A, Wittel UA, von Elverfeldt D, Reichardt W, Boerries M, Andrieux G, Heynen GJ, Fichtner-Feigl S, Hannibal L, Ruess DA. Vertical RAS pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterations. Signal Transduct Target Ther. 2026 Jan 16;11(1):33. doi: 10.1038/s41392-025-02563-7.
Zwick M, Zinkel B, Spohr C, Rückert T, Halbach S, Shoumariyeh K, Scheid J, Baur AS, Braun LM, Angel M, Michaeli E, Todkar A, Nelde A, Märklin M, Holzmayer SJ, Dicks S, Boerries M, Duquesne S, Schlaak AE, Otto-Mora P, Bengsch B, Schiff M, Kissel S, Selle M, Follo M, Altmann H, Kunadt D, Illert AL, Walz JS, Walz G, Duyster J, Schetelig J, Brummer T, Zeiser R, Köhler N. FLT3-ITD Induces CMTM6 and Enhances Immune Escape in Acute Myeloid Leukemia. Cancer Res. 2026 Jan 16;86(2):367-386. doi: 10.1158/0008-5472.CAN-25-0349.
Tangermann C, Ghosh A, Ziegler M, Facchinetti F, Stappenbeck J, Carus Sahin YO, Riester M, Viardot LC, Zundel T, Friboulet L, Hollebecque A, Naveja JJ, Wanninger A, Hess ME, Brummer T, Boerries M, Loges S, Loriot Y, Illert AL, Diederichs S. Saturation mutagenesis identifies activating and resistance-inducing FGFR kinase domain mutations. Nat Genet. 2026 Jan;58(1):157-168. doi: 10.1038/s41588-025-02431-8. Epub 2025 Dec 8.
Braun LM, Zeiser R. Cutting without cleaving: How caspase-1 shapes leukemia beyond enzymatic activity. Cell Chem Biol. 2026 Jan 15;33(1):1-3. doi: 10.1016/j.chembiol.2025.12.011.
Watter M, Giuliani C, Benadi G, Engel F, Binder H, Kaier K. Automated identification of contextually relevant biomedical entities with grounded LLMs. Sci Rep. 2026 Jan 13;16(1):1952. doi: 10.1038/s41598-026-35492-8.
Kaier K, Engel F, Benadi G, Giuliani C, Watter M, Kalantari A, Schuller K, Franzke CW, Sperandio M, Binder H. Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. BMC Res Notes. 2026 Jan 12;19(1):43. doi: 10.1186/s13104-026-07632-w.PMC12837611.
