Project Summary
The transcription factor NFE2 constitutes an oncogene in myeloproliferative neoplasms (MPNs) and directly activates TGFB1 transcription, resulting in increased TGF-β production in both mouse and human B cells. This NFE2/TGF-β axis correlates with impaired B-cell maturation and immunosuppression. The project aims to define the molecular mechanisms linking NFE2 activity, TGF-β production, and immune dysfunction, particularly focusing on B cells. Using NFE2-modulated mouse models, gene reporter assays, and interactome studies, therapeutic targets within this pathway will be identified.
