Harald Binder

Principal Investigator

Institute of Medical Biometry and Statistics
Faculty of Medicine and Medical Center University of Freiburg

Stefan-Meier-Str. 26
79104 Freiburg

Current position

W3 Professor and Director of the Institute of Medical Biometry and Statistics, 
Faculty of Medicine and Medical Center University of Freiburg

Academic training

2001–2006Ph.D. studies, Statistics, Ludwigs-Maximilians-Universität München
2000–2001M.A. Mathematical Behavioural Sciences, University of California Irvine, USA
1996–2000 Diploma studies, Psychology, University of Regensburg

Advanced academic qualifications

2011Habilitation (Medical Biometry and Statistics), Albert-Ludwigs-Universität Freiburg
2006Promotion/PhD (Statistics), Ludwig-Maximilians-University, Munich
2001Master of Arts in Mathematical Behavioral Sciences, University of California, Irvine, CA, USA

Postgraduate Positions

Since 2017W3 Professor for Medical Biometry and Director, Institute of Medical Biometry and Statistics, Medical Center University of Freiburg
2011 - 2017Professor for Medical Biometry, University Medical Center Mainz, Germany
2006 - 2011Research Associate, Institute for Medical Biometry and Medical Informatics, Medical Center University of Freiburg
2001 - 2006Researcher, Department of Psychiatry, University of Regensburg

Miscellaneous (Honors, Awards)

Since 2023Speaker of CRC 1597 “Small Data”
2021–2023President of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS) e.V.
2021–2023Elected Member, Senate of the University of Freiburg
Since 2018Member of the Board, Clinical Trials Unit, Medical Center, University of Freiburg
Since 2017Member of the Board, Freiburg Center for Data Analysis and Modelling

Publications listed in PubMed®

Publications (based on CRC1479 funding)

Watter M, Giuliani C, Benadi G, Engel F, Binder H, Kaier K. Automated identification of contextually relevant biomedical entities with grounded LLMs. Sci Rep. 2026 Jan 13;16(1):1952. doi: 10.1038/s41598-026-35492-8.
Kaier K, Engel F, Benadi G, Giuliani C, Watter M, Kalantari A, Schuller K, Franzke CW, Sperandio M, Binder H. Identification of biomedical entities from multiple repositories using a specialized metadata schema and search-augmented large language models. BMC Res Notes. 2026 Jan 12;19(1):43. doi: 10.1186/s13104-026-07632-w.PMC12837611.
Giuliani C, Benadi G, Engel F, Werner J, Watter M, Schwarzer G, Groß O, Zeiser R, Binder H, Kaier K. Identifying Biomedical Entities for Datasets in Scientific Articles: 4-Step Cache-Augmented Generation Approach Using GPT-4o and PubTator 3.0. JMIR Form Res. 2025 Nov 20;9:e73822. doi: 10.2196/73822.

Watter M, Kahle L, Brunswiek B, Fichtner UA, Pfaffenlehner M, Werner F, Gebele D, Binder H, and Knaus J, “Standardized Metadata Collection to Reinforce Collaboration in Collaborative Research Centers,” in E-Science-Tage 2023: Empower Your Research ? Preserve Your Data, (Vincent Heuveline, Nina Bisheh, and Philipp Kling, eds.), pp. 282-288, 2023.

Barsch M, Salié H, Schlaak AE, Zhang Z, Hess M, Mayer LS, Tauber C, Otto-Mora P, Ohtani T, Nilsson T, Wischer L, Winkler F, Manne S, Rech A, Schmitt-Graeff A, Bronsert P, Hofmann M, Neumann-Haefelin C, Boettler T, Fichtner-Feigl S, van Boemmel F, Berg T, Rimassa L, Di Tommaso L, Saeed A, D’Alessio A, Pinato DJ, Bettinger D, Binder H, John Wherry E, Schultheiss M, Thimme R, Bengsch B. T-cell exhaustion and residency dynamics inform clinical outcomes in hepatocellular carcinoma. J Hepatol. 2022 Aug;77(2):397-409. doi: 10.1016/j.jhep.2022.02.032. Epub 2022 Apr 1.